A matched crossover design for clinical trials
نویسندگان
چکیده
منابع مشابه
Crossover Designs for Two-treatment Clinical Trials
Crossover designs in clinical trials are very popular for comparing several non-curative treatments for their eecacy, while having each patient as his/her own control. Many investigators have constructed universally optimal designs for certain repeated measurement experiments. However, most of these statistically optimal designs have certain undesirable features from a clinical perspective. In ...
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BACKGROUND The cluster randomized crossover (CRXO) design is gaining popularity in trial settings where individual randomization or parallel group cluster randomization is not feasible or practical. In a CRXO trial, not only are clusters of individuals rather than individuals themselves randomized to trial arms, but also each cluster participates in each arm of the trial at least once in separa...
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OBJECTIVE Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials. METHODS We searched MEDLINE for December 2000 and identified all randomized crossover trials. We abstracted data independently, in duplicate, on 14 design criter...
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ژورنال
عنوان ژورنال: Contemporary Clinical Trials
سال: 2007
ISSN: 1551-7144
DOI: 10.1016/j.cct.2007.02.003